Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology.
Identifieur interne : 000431 ( Main/Exploration ); précédent : 000430; suivant : 000432Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology.
Auteurs : Thomas M. Gorter [Pays-Bas] ; Dirk J. Van Veldhuisen [Pays-Bas] ; Johann Bauersachs [Allemagne] ; Barry A. Borlaug [États-Unis] ; Jelena Celutkiene [Lituanie] ; Andrew J S. Coats [Australie] ; Marisa G. Crespo-Leiro [Espagne] ; Marco Guazzi [Italie] ; Veli-Pekka Harjola [Finlande] ; Stephane Heymans [Pays-Bas] ; Loreena Hill [Royaume-Uni] ; Mitja Lainscak [Slovénie] ; Carolyn S P. Lam [Singapour] ; Lars H. Lund [Suède] ; Alexander R. Lyon [Royaume-Uni] ; Alexandre Mebazaa [France] ; Christian Mueller [Suisse] ; Walter J. Paulus [Pays-Bas] ; Burkert Pieske [Allemagne] ; Massimo F. Piepoli [Italie] ; Frank Ruschitzka [Suisse] ; Frans H. Rutten [Pays-Bas] ; Petar M. Seferovic [Serbie] ; Scott D. Solomon [États-Unis] ; Sanjiv J. Shah [États-Unis] ; Filippos Triposkiadis [Grèce] ; Rolf Wachter ; Carsten Tschöpe [Allemagne] ; Rudolf A. De Boer [Pays-Bas]Source :
- European journal of heart failure [ 1879-0844 ] ; 2017.
Abstract
There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.
DOI: 10.1002/ejhf.1029
PubMed: 29044932
Affiliations:
- Allemagne, Australie, Espagne, Finlande, France, Grèce, Italie, Lituanie, Pays-Bas, Royaume-Uni, Serbie, Singapour, Slovénie, Suisse, Suède, États-Unis
- Angleterre, Basse-Saxe, Berlin, Canton de Zurich, Grand Londres, Groningue (province), Hollande-Septentrionale, Illinois, Lombardie, Massachusetts, Minnesota, Svealand, Utrecht (province), Uusimaa, Île-de-France
- Amsterdam, Berlin, Groningue, Hanovre, Helsinki, Londres, Milan, Paris, Stockholm, Utrecht, Zurich
- Université d'Helsinki
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Crespo-Leiro</name><affiliation wicri:level="1"><nlm:affiliation>Advanced Heart Failure and Heart Transplant Unit, Servicio de Cardiologia-CIBERCV, Complejo Hospitalario Universitario A Coruña (CHUAC), Instituto Investigación Biomedica A Coruña (INIBIC), Universidad da Coruña (UDC), La Coruña, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Advanced Heart Failure and Heart Transplant Unit, Servicio de Cardiologia-CIBERCV, Complejo Hospitalario Universitario A Coruña (CHUAC), Instituto Investigación Biomedica A Coruña (INIBIC), Universidad da Coruña (UDC), La Coruña</wicri:regionArea><wicri:noRegion>La Coruña</wicri:noRegion></affiliation></author><author><name sortKey="Guazzi, Marco" sort="Guazzi, Marco" uniqKey="Guazzi M" first="Marco" last="Guazzi">Marco Guazzi</name><affiliation wicri:level="3"><nlm:affiliation>Heart Failure Unit, University of Milan, IRCCS Policlinico San Donato, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Heart Failure Unit, University of Milan, IRCCS Policlinico San Donato, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Harjola, Veli Pekka" sort="Harjola, Veli Pekka" uniqKey="Harjola V" first="Veli-Pekka" last="Harjola">Veli-Pekka Harjola</name><affiliation wicri:level="4"><nlm:affiliation>Emergency Medicine, University of Helsinki, Department of Emergency Medicine and Services, Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Emergency Medicine, University of Helsinki, Department of Emergency Medicine and Services, Helsinki University Hospital, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Heymans, Stephane" sort="Heymans, Stephane" uniqKey="Heymans S" first="Stephane" last="Heymans">Stephane Heymans</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Loreena" sort="Hill, Loreena" uniqKey="Hill L" first="Loreena" last="Hill">Loreena Hill</name><affiliation wicri:level="1"><nlm:affiliation>Queen's University, Belfast, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen's University, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Lainscak, Mitja" sort="Lainscak, Mitja" uniqKey="Lainscak M" first="Mitja" last="Lainscak">Mitja Lainscak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, General Hospital Murska Sobota, Murska Sobota, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Internal Medicine, General Hospital Murska Sobota, Murska Sobota</wicri:regionArea><wicri:noRegion>Murska Sobota</wicri:noRegion></affiliation></author><author><name sortKey="Lam, Carolyn S P" sort="Lam, Carolyn S P" uniqKey="Lam C" first="Carolyn S P" last="Lam">Carolyn S P. Lam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, National Heart Center Singapore, Singapore Duke-NUS Graduate Medical School, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Cardiology, National Heart Center Singapore, Singapore Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>Singapore Duke-NUS Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Lund, Lars H" sort="Lund, Lars H" uniqKey="Lund L" first="Lars H" last="Lund">Lars H. Lund</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Karolinska Institutet and Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine, Karolinska Institutet and Heart and Vascular Theme, Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Lyon, Alexander R" sort="Lyon, Alexander R" uniqKey="Lyon A" first="Alexander R" last="Lyon">Alexander R. Lyon</name><affiliation wicri:level="3"><nlm:affiliation>National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mebazaa, Alexandre" sort="Mebazaa, Alexandre" uniqKey="Mebazaa A" first="Alexandre" last="Mebazaa">Alexandre Mebazaa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology and Critical Care, APHP - Saint Louis Lariboisière University Hospitals, University Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Anesthesiology and Critical Care, APHP - Saint Louis Lariboisière University Hospitals, University Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mueller, Christian" sort="Mueller, Christian" uniqKey="Mueller C" first="Christian" last="Mueller">Christian Mueller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Paulus, Walter J" sort="Paulus, Walter J" uniqKey="Paulus W" first="Walter J" last="Paulus">Walter J. Paulus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Pieske, Burkert" sort="Pieske, Burkert" uniqKey="Pieske B" first="Burkert" last="Pieske">Burkert Pieske</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine and Cardiology, Charité University Medicine, Berlin, Germany, and Department of Internal Medicine Cardiology, German Heart Center Berlin, DZHK (German Center for Cardiovascular Research) and Berlin Institute of Health (BIH), Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine and Cardiology, Charité University Medicine, Berlin, Germany, and Department of Internal Medicine Cardiology, German Heart Center Berlin, DZHK (German Center for Cardiovascular Research) and Berlin Institute of Health (BIH), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Piepoli, Massimo F" sort="Piepoli, Massimo F" uniqKey="Piepoli M" first="Massimo F" last="Piepoli">Massimo F. Piepoli</name><affiliation wicri:level="1"><nlm:affiliation>Heart Failure Unit, Cardiac Department, G. da Saliceto Hospital, Piacenza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Heart Failure Unit, Cardiac Department, G. da Saliceto Hospital, Piacenza</wicri:regionArea><wicri:noRegion>Piacenza</wicri:noRegion></affiliation></author><author><name sortKey="Ruschitzka, Frank" sort="Ruschitzka, Frank" uniqKey="Ruschitzka F" first="Frank" last="Ruschitzka">Frank Ruschitzka</name><affiliation wicri:level="3"><nlm:affiliation>Clinic for Cardiology, University Hospital Zurich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Clinic for Cardiology, University Hospital Zurich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Rutten, Frans H" sort="Rutten, Frans H" uniqKey="Rutten F" first="Frans H" last="Rutten">Frans H. Rutten</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Seferovic, Petar M" sort="Seferovic, Petar M" uniqKey="Seferovic P" first="Petar M" last="Seferovic">Petar M. Seferovic</name><affiliation wicri:level="1"><nlm:affiliation>Cardiology Department, Clinical Centre Serbia, Medical School, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Cardiology Department, Clinical Centre Serbia, Medical School, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Solomon, Scott D" sort="Solomon, Scott D" uniqKey="Solomon S" first="Scott D" last="Solomon">Scott D. Solomon</name><affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Division, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Shah, Sanjiv J" sort="Shah, Sanjiv J" uniqKey="Shah S" first="Sanjiv J" last="Shah">Sanjiv J. Shah</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Triposkiadis, Filippos" sort="Triposkiadis, Filippos" uniqKey="Triposkiadis F" first="Filippos" last="Triposkiadis">Filippos Triposkiadis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Larissa University Hospital, Larissa, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Cardiology, Larissa University Hospital, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Wachter, Rolf" sort="Wachter, Rolf" uniqKey="Wachter R" first="Rolf" last="Wachter">Rolf Wachter</name><affiliation><nlm:affiliation>Clinic and Policlinic for Cardiology, University Hospital Leipzig, Leipzig, Germany and German Cardiovascular Research Center, partner site Göttingen.</nlm:affiliation><wicri:noCountry code="subField">partner site Göttingen</wicri:noCountry></affiliation></author><author><name sortKey="Tschope, Carsten" sort="Tschope, Carsten" uniqKey="Tschope C" first="Carsten" last="Tschöpe">Carsten Tschöpe</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine and Cardiology, Charité University Medicine, Berlin, Germany, and Department of Internal Medicine Cardiology, German Heart Center Berlin, DZHK (German Center for Cardiovascular Research) and Berlin Institute of Health (BIH), Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine and Cardiology, Charité University Medicine, Berlin, Germany, and Department of Internal Medicine Cardiology, German Heart Center Berlin, DZHK (German Center for Cardiovascular Research) and Berlin Institute of Health (BIH), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A" last="De Boer">Rudolf A. De Boer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29044932</idno><idno type="pmid">29044932</idno><idno type="doi">10.1002/ejhf.1029</idno><idno type="wicri:Area/PubMed/Corpus">000369</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000369</idno><idno type="wicri:Area/PubMed/Curation">000367</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000367</idno><idno type="wicri:Area/PubMed/Checkpoint">000367</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000367</idno><idno type="wicri:Area/Ncbi/Merge">005055</idno><idno type="wicri:Area/Ncbi/Curation">005055</idno><idno type="wicri:Area/Ncbi/Checkpoint">005055</idno><idno type="wicri:Area/Main/Merge">000426</idno><idno type="wicri:Area/Main/Curation">000431</idno><idno type="wicri:Area/Main/Exploration">000431</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology.</title><author><name sortKey="Gorter, Thomas M" sort="Gorter, Thomas M" uniqKey="Gorter T" first="Thomas M" last="Gorter">Thomas M. Gorter</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J" last="Van Veldhuisen">Dirk J. Van Veldhuisen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Bauersachs, Johann" sort="Bauersachs, Johann" uniqKey="Bauersachs J" first="Johann" last="Bauersachs">Johann Bauersachs</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology and Angiology, Medical School Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Borlaug, Barry A" sort="Borlaug, Barry A" uniqKey="Borlaug B" first="Barry A" last="Borlaug">Barry A. Borlaug</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Celutkiene, Jelena" sort="Celutkiene, Jelena" uniqKey="Celutkiene J" first="Jelena" last="Celutkiene">Jelena Celutkiene</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Clinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Coats, Andrew J S" sort="Coats, Andrew J S" uniqKey="Coats A" first="Andrew J S" last="Coats">Andrew J S. Coats</name><affiliation wicri:level="1"><nlm:affiliation>Monash University, Clayton Campus, Melbourne, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Clayton Campus, Melbourne, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Crespo Leiro, Marisa G" sort="Crespo Leiro, Marisa G" uniqKey="Crespo Leiro M" first="Marisa G" last="Crespo-Leiro">Marisa G. Crespo-Leiro</name><affiliation wicri:level="1"><nlm:affiliation>Advanced Heart Failure and Heart Transplant Unit, Servicio de Cardiologia-CIBERCV, Complejo Hospitalario Universitario A Coruña (CHUAC), Instituto Investigación Biomedica A Coruña (INIBIC), Universidad da Coruña (UDC), La Coruña, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Advanced Heart Failure and Heart Transplant Unit, Servicio de Cardiologia-CIBERCV, Complejo Hospitalario Universitario A Coruña (CHUAC), Instituto Investigación Biomedica A Coruña (INIBIC), Universidad da Coruña (UDC), La Coruña</wicri:regionArea><wicri:noRegion>La Coruña</wicri:noRegion></affiliation></author><author><name sortKey="Guazzi, Marco" sort="Guazzi, Marco" uniqKey="Guazzi M" first="Marco" last="Guazzi">Marco Guazzi</name><affiliation wicri:level="3"><nlm:affiliation>Heart Failure Unit, University of Milan, IRCCS Policlinico San Donato, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Heart Failure Unit, University of Milan, IRCCS Policlinico San Donato, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Harjola, Veli Pekka" sort="Harjola, Veli Pekka" uniqKey="Harjola V" first="Veli-Pekka" last="Harjola">Veli-Pekka Harjola</name><affiliation wicri:level="4"><nlm:affiliation>Emergency Medicine, University of Helsinki, Department of Emergency Medicine and Services, Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Emergency Medicine, University of Helsinki, Department of Emergency Medicine and Services, Helsinki University Hospital, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Heymans, Stephane" sort="Heymans, Stephane" uniqKey="Heymans S" first="Stephane" last="Heymans">Stephane Heymans</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Loreena" sort="Hill, Loreena" uniqKey="Hill L" first="Loreena" last="Hill">Loreena Hill</name><affiliation wicri:level="1"><nlm:affiliation>Queen's University, Belfast, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen's University, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Lainscak, Mitja" sort="Lainscak, Mitja" uniqKey="Lainscak M" first="Mitja" last="Lainscak">Mitja Lainscak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, General Hospital Murska Sobota, Murska Sobota, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Internal Medicine, General Hospital Murska Sobota, Murska Sobota</wicri:regionArea><wicri:noRegion>Murska Sobota</wicri:noRegion></affiliation></author><author><name sortKey="Lam, Carolyn S P" sort="Lam, Carolyn S P" uniqKey="Lam C" first="Carolyn S P" last="Lam">Carolyn S P. Lam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, National Heart Center Singapore, Singapore Duke-NUS Graduate Medical School, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Cardiology, National Heart Center Singapore, Singapore Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>Singapore Duke-NUS Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Lund, Lars H" sort="Lund, Lars H" uniqKey="Lund L" first="Lars H" last="Lund">Lars H. Lund</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Karolinska Institutet and Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine, Karolinska Institutet and Heart and Vascular Theme, Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Lyon, Alexander R" sort="Lyon, Alexander R" uniqKey="Lyon A" first="Alexander R" last="Lyon">Alexander R. Lyon</name><affiliation wicri:level="3"><nlm:affiliation>National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mebazaa, Alexandre" sort="Mebazaa, Alexandre" uniqKey="Mebazaa A" first="Alexandre" last="Mebazaa">Alexandre Mebazaa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology and Critical Care, APHP - Saint Louis Lariboisière University Hospitals, University Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Anesthesiology and Critical Care, APHP - Saint Louis Lariboisière University Hospitals, University Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mueller, Christian" sort="Mueller, Christian" uniqKey="Mueller C" first="Christian" last="Mueller">Christian Mueller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Paulus, Walter J" sort="Paulus, Walter J" uniqKey="Paulus W" first="Walter J" last="Paulus">Walter J. Paulus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Pieske, Burkert" sort="Pieske, Burkert" uniqKey="Pieske B" first="Burkert" last="Pieske">Burkert Pieske</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine and Cardiology, Charité University Medicine, Berlin, Germany, and Department of Internal Medicine Cardiology, German Heart Center Berlin, DZHK (German Center for Cardiovascular Research) and Berlin Institute of Health (BIH), Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine and Cardiology, Charité University Medicine, Berlin, Germany, and Department of Internal Medicine Cardiology, German Heart Center Berlin, DZHK (German Center for Cardiovascular Research) and Berlin Institute of Health (BIH), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Piepoli, Massimo F" sort="Piepoli, Massimo F" uniqKey="Piepoli M" first="Massimo F" last="Piepoli">Massimo F. Piepoli</name><affiliation wicri:level="1"><nlm:affiliation>Heart Failure Unit, Cardiac Department, G. da Saliceto Hospital, Piacenza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Heart Failure Unit, Cardiac Department, G. da Saliceto Hospital, Piacenza</wicri:regionArea><wicri:noRegion>Piacenza</wicri:noRegion></affiliation></author><author><name sortKey="Ruschitzka, Frank" sort="Ruschitzka, Frank" uniqKey="Ruschitzka F" first="Frank" last="Ruschitzka">Frank Ruschitzka</name><affiliation wicri:level="3"><nlm:affiliation>Clinic for Cardiology, University Hospital Zurich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Clinic for Cardiology, University Hospital Zurich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Rutten, Frans H" sort="Rutten, Frans H" uniqKey="Rutten F" first="Frans H" last="Rutten">Frans H. Rutten</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Seferovic, Petar M" sort="Seferovic, Petar M" uniqKey="Seferovic P" first="Petar M" last="Seferovic">Petar M. Seferovic</name><affiliation wicri:level="1"><nlm:affiliation>Cardiology Department, Clinical Centre Serbia, Medical School, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Cardiology Department, Clinical Centre Serbia, Medical School, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Solomon, Scott D" sort="Solomon, Scott D" uniqKey="Solomon S" first="Scott D" last="Solomon">Scott D. Solomon</name><affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Division, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Shah, Sanjiv J" sort="Shah, Sanjiv J" uniqKey="Shah S" first="Sanjiv J" last="Shah">Sanjiv J. Shah</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Triposkiadis, Filippos" sort="Triposkiadis, Filippos" uniqKey="Triposkiadis F" first="Filippos" last="Triposkiadis">Filippos Triposkiadis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Larissa University Hospital, Larissa, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Cardiology, Larissa University Hospital, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Wachter, Rolf" sort="Wachter, Rolf" uniqKey="Wachter R" first="Rolf" last="Wachter">Rolf Wachter</name><affiliation><nlm:affiliation>Clinic and Policlinic for Cardiology, University Hospital Leipzig, Leipzig, Germany and German Cardiovascular Research Center, partner site Göttingen.</nlm:affiliation><wicri:noCountry code="subField">partner site Göttingen</wicri:noCountry></affiliation></author><author><name sortKey="Tschope, Carsten" sort="Tschope, Carsten" uniqKey="Tschope C" first="Carsten" last="Tschöpe">Carsten Tschöpe</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine and Cardiology, Charité University Medicine, Berlin, Germany, and Department of Internal Medicine Cardiology, German Heart Center Berlin, DZHK (German Center for Cardiovascular Research) and Berlin Institute of Health (BIH), Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine and Cardiology, Charité University Medicine, Berlin, Germany, and Department of Internal Medicine Cardiology, German Heart Center Berlin, DZHK (German Center for Cardiovascular Research) and Berlin Institute of Health (BIH), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A" last="De Boer">Rudolf A. De Boer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author></analytic><series><title level="j">European journal of heart failure</title><idno type="eISSN">1879-0844</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Lituanie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Serbie</li><li>Singapour</li><li>Slovénie</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Basse-Saxe</li><li>Berlin</li><li>Canton de Zurich</li><li>Grand Londres</li><li>Groningue (province)</li><li>Hollande-Septentrionale</li><li>Illinois</li><li>Lombardie</li><li>Massachusetts</li><li>Minnesota</li><li>Svealand</li><li>Utrecht (province)</li><li>Uusimaa</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Berlin</li><li>Groningue</li><li>Hanovre</li><li>Helsinki</li><li>Londres</li><li>Milan</li><li>Paris</li><li>Stockholm</li><li>Utrecht</li><li>Zurich</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Wachter, Rolf" sort="Wachter, Rolf" uniqKey="Wachter R" first="Rolf" last="Wachter">Rolf Wachter</name></noCountry><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Gorter, Thomas M" sort="Gorter, Thomas M" uniqKey="Gorter T" first="Thomas M" last="Gorter">Thomas M. Gorter</name></region><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A" last="De Boer">Rudolf A. De Boer</name><name sortKey="Heymans, Stephane" sort="Heymans, Stephane" uniqKey="Heymans S" first="Stephane" last="Heymans">Stephane Heymans</name><name sortKey="Paulus, Walter J" sort="Paulus, Walter J" uniqKey="Paulus W" first="Walter J" last="Paulus">Walter J. Paulus</name><name sortKey="Rutten, Frans H" sort="Rutten, Frans H" uniqKey="Rutten F" first="Frans H" last="Rutten">Frans H. Rutten</name><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J" last="Van Veldhuisen">Dirk J. Van Veldhuisen</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Bauersachs, Johann" sort="Bauersachs, Johann" uniqKey="Bauersachs J" first="Johann" last="Bauersachs">Johann Bauersachs</name></region><name sortKey="Pieske, Burkert" sort="Pieske, Burkert" uniqKey="Pieske B" first="Burkert" last="Pieske">Burkert Pieske</name><name sortKey="Tschope, Carsten" sort="Tschope, Carsten" uniqKey="Tschope C" first="Carsten" last="Tschöpe">Carsten Tschöpe</name></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Borlaug, Barry A" sort="Borlaug, Barry A" uniqKey="Borlaug B" first="Barry A" last="Borlaug">Barry A. Borlaug</name></region><name sortKey="Shah, Sanjiv J" sort="Shah, Sanjiv J" uniqKey="Shah S" first="Sanjiv J" last="Shah">Sanjiv J. Shah</name><name sortKey="Solomon, Scott D" sort="Solomon, Scott D" uniqKey="Solomon S" first="Scott D" last="Solomon">Scott D. Solomon</name></country><country name="Lituanie"><noRegion><name sortKey="Celutkiene, Jelena" sort="Celutkiene, Jelena" uniqKey="Celutkiene J" first="Jelena" last="Celutkiene">Jelena Celutkiene</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Coats, Andrew J S" sort="Coats, Andrew J S" uniqKey="Coats A" first="Andrew J S" last="Coats">Andrew J S. Coats</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Crespo Leiro, Marisa G" sort="Crespo Leiro, Marisa G" uniqKey="Crespo Leiro M" first="Marisa G" last="Crespo-Leiro">Marisa G. Crespo-Leiro</name></noRegion></country><country name="Italie"><region name="Lombardie"><name sortKey="Guazzi, Marco" sort="Guazzi, Marco" uniqKey="Guazzi M" first="Marco" last="Guazzi">Marco Guazzi</name></region><name sortKey="Piepoli, Massimo F" sort="Piepoli, Massimo F" uniqKey="Piepoli M" first="Massimo F" last="Piepoli">Massimo F. Piepoli</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Harjola, Veli Pekka" sort="Harjola, Veli Pekka" uniqKey="Harjola V" first="Veli-Pekka" last="Harjola">Veli-Pekka Harjola</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Hill, Loreena" sort="Hill, Loreena" uniqKey="Hill L" first="Loreena" last="Hill">Loreena Hill</name></noRegion><name sortKey="Lyon, Alexander R" sort="Lyon, Alexander R" uniqKey="Lyon A" first="Alexander R" last="Lyon">Alexander R. Lyon</name></country><country name="Slovénie"><noRegion><name sortKey="Lainscak, Mitja" sort="Lainscak, Mitja" uniqKey="Lainscak M" first="Mitja" last="Lainscak">Mitja Lainscak</name></noRegion></country><country name="Singapour"><noRegion><name sortKey="Lam, Carolyn S P" sort="Lam, Carolyn S P" uniqKey="Lam C" first="Carolyn S P" last="Lam">Carolyn S P. Lam</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Lund, Lars H" sort="Lund, Lars H" uniqKey="Lund L" first="Lars H" last="Lund">Lars H. Lund</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Mebazaa, Alexandre" sort="Mebazaa, Alexandre" uniqKey="Mebazaa A" first="Alexandre" last="Mebazaa">Alexandre Mebazaa</name></region></country><country name="Suisse"><noRegion><name sortKey="Mueller, Christian" sort="Mueller, Christian" uniqKey="Mueller C" first="Christian" last="Mueller">Christian Mueller</name></noRegion><name sortKey="Ruschitzka, Frank" sort="Ruschitzka, Frank" uniqKey="Ruschitzka F" first="Frank" last="Ruschitzka">Frank Ruschitzka</name></country><country name="Serbie"><noRegion><name sortKey="Seferovic, Petar M" sort="Seferovic, Petar M" uniqKey="Seferovic P" first="Petar M" last="Seferovic">Petar M. Seferovic</name></noRegion></country><country name="Grèce"><noRegion><name sortKey="Triposkiadis, Filippos" sort="Triposkiadis, Filippos" uniqKey="Triposkiadis F" first="Filippos" last="Triposkiadis">Filippos Triposkiadis</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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